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Ibuprofen Cocrystal Preparation and Structure Study Using Fluorescence Spectrometry

Dewei Zhao, Hua Ma, Ning Qiao
Vol. 4, No. 10, pp. 54-60, 2022 DOI: 10.54691/sjt.v4i10.2490 October 23, 2022
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Abstract.Ibuprofen (IBU) was cocrystallized with nicotinamide (NIC), saccharin (SAC) and succinic acid (SUC) using solvent evaporation method and grinding method. Ibuprofen cocrystals were characterized by FTIR, XRD to analyze crystalline structure. Fluorescence spectrometer (FS) was also applied to verify the formation of ibuprofen cocrystals. The formation of IBU-NIC cocrystal, IBU-SAC cocrystal and IBU-SUC cocrystal were demonstrated by IR character peaks shift and new XRD character peaks. Solution method can produce IBU cocrystal with higher purity. The change of maximal fluorescence emission wavelength and strength can be used to verify the formation of cocrystal.
Keywords. Ibuprofen; Nicotinamide; Saccharin; Succinic Acid; Cocrystal.
APA Citation Dewei Zhao, Hua Ma, Ning Qiao (2022). Ibuprofen Cocrystal Preparation and Structure Study Using Fluorescence Spectrometry. Scientific Journal of Technology, 4(10), 54-60. https://doi.org/10.54691/sjt.v4i10.2490

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