Kaidi Song, Meng Li, Zhenlin Wei
Abstract.Ferroptosis is a novel modifiable mode of cell death. Mulberry extract has antioxidant capacity, a hepatoprotective effect, and the ability to alleviate carbon tetrachloride-induced liver injury. However, whether it can complex iron ions and inhibit the activity of the key enzyme of Ferroptosis has not yet been reported. In this study, we used virtual screening, molecular docking, and molecular dynamics analysis to elucidate the anti-Ferroptosis components and mechanism of action in mulberry.
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Juanjuan Zhao, Xiaoyan Song, Xueyuan Shu, Huaying Zhang, Liutao Han
Abstract.Slag-fly ash-metakaolin geopolymer concrete (GPC) uses industrial solid wastes (slag, fly ash) and natural minerals (metakaolin) as precursors, which undergo polycondensation reactions induced by alkali activators to form a zeolite-like aluminosilicate three-dimensional network structure. It not only has the advantages of low carbon and environmental protection, high strength, and good durability, but also shows excellent high-temperature resistance potential. It is a new type of green cementitious material that can replace traditional ordinary Portland cement (OPC) concrete and adapt to …
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Xin Dong, Juannong Chen
Abstract.The Saint-Venant principle is a classical theory in solid mechanics. The core idea is that the influence of external force on the internal stress and deformation of the solid will gradually weaken to be negligible away from the load area. In this paper, Abaqus finite element software is used to establish a three-dimensional model to study the influence of different load distribution ( point load, line load and uniform load ) on the stress field. The cube model is selected as the analysis object, and the concentrated load and uniform distribution load are applied. By analyzing the stress …
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Qijun Wang, Can Su, Hang Liu, Rui Zhou
Abstract.To address the challenges faced by traditional fluxgate magnetic gradient meters in achieving multi-axis synchronous measurement, such as orthogonality among the three axes, channel consistency, and structural integration, a highly integrated magnetic gradient sensor design based on a center-symmetric orthogonal structure is proposed. The design integrates the three-axis differential sensing units into a compact whole through an integrated three-dimensional orthogonal coil frame, achieving a high degree of physical parameter matching among the channels. On this basis, combined with the reverse …
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Jia Gao, Guanglei Qiang, Lihua Zhu
Abstract.In the era of the digital economy, Artificial Intelligence (AI), as the core driving force of the new generation of information technology, has become a key support for promoting the transformation and upgrading of local industries and enhancing industrial core competitiveness. Currently, local industries in China are facing development bottlenecks such as homogeneous competition, low-end locking of industrial chains, insufficient innovation capability, and relatively low production efficiency. The deep integration of AI technology can effectively address these industrial development pain …
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Peng Yin
Abstract.Since the failure of the Scan Line Corrector (SLC) on the Landsat 7 ETM+ sensor in 2003, approximately 22% of pixels in acquired images are missing in a regular stripe pattern, severely limiting their application in time-series analysis and land cover monitoring. To address the limitations of traditional methods in modeling complex land surfaces and their tendency to introduce spectral distortions, this paper proposes a stripe-aware deep learning restoration network called SINet (Stripe Inpainting Network). The network leverages a Stripe Attention Module (SAM) to exploit the geometric prior of …
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Yuxi Han
Abstract.As a classic paradigm of two-stage target detection, Mask R-CNN achieves robust instance awareness through regional proposal and feature alignment. In its structure, the backbone network is responsible for extracting multi-scale features from the image layer by layer, and usually uses convolutional networks such as RESNET, which is difficult to use the global context prior to suppress the background noise in the degraded environment; Neck network (neck) relies on fixed multi-scale fusion scheme, lacks the ability of adaptive expression for different image contents, and is limited by the local …
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Jinyu Li
Abstract.Microbial cell factories represent a cornerstone technology for sustainable biomanufacturing, offering environmentally friendly alternatives to traditional petrochemical synthesis. This review examines recent advances in metabolic engineering strategies employed to optimize microbial production platforms for high-value compounds, including pharmaceuticals, nutraceuticals, biofuels, and specialty chemicals. We systematically analyze the integration of systems biology approaches, synthetic biology tools, and computational methods that have revolutionized strain development. Our comprehensive …
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Meiting Zhan, Qianying Wu, Ziyi Liu, Qingyuan Liu, Ye Ju
Abstract.AI technology is reshaping the paradigm of cross-border financial data flows within the digital trade framework, shifting from static transmission to dynamic collaboration and giving rise to threefold risks: data breaches, algorithmic abuse, and sovereignty conflicts. Traditional regulatory logic centered on territorial jurisdiction and post-incident accountability is becoming obsolete. Fragmented international rules lead to regulatory arbitrage and inefficient dispute resolution. A transformative pathway emerges, grounded in three theoretical pillars: sovereignty constraints, collaborative …
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Huaying Zhang, Jingyuan Wang, Wenmei Cao, Ying Ba
Abstract.The aging process of China's population is accelerating continuously, and falls among the elderly have become a core pain point in the fields of home-based elderly care and geriatric rehabilitation, with gait instability being the primary cause of falls. Traditional gait training equipment suffers from high costs, poor adaptability to home environments, and high feedback delays, making it difficult to meet the demand for inclusive elderly care. Focusing on the research and development of an intelligent gait training system for fall prevention in the elderly, this paper conducts a comprehensive …
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Feifei Wang, Qing Zhao, Mengyu Shi
Abstract.In the new stage of deep integration between global competition and localized operations, building a scientific, systematic, and operable "automotive overseas product capability evaluation system" is of key significance for promoting the sustainable international development of Chinese automobile enterprises with product value as the core. Based on the international competitive practices of Chinese automotive products, this study proposes a dual evaluation dimension of "intrinsic quality" and "appealing quality" to construct an automotive product evaluation system that meets the requirements …
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Haimeng Ni, Mayu Qiukang, Ziyu Wang, Rongfang Feng
Abstract.To clarify the varietal characteristics and supporting production technologies of Bijie white garlic, and improve its yield, quality and cultivation efficiency, this paper takes Guizhou Bijie white garlic as the research object. By combining literature review and field production practice summary, it systematically studies its species overview, biological characteristics, morphological characteristics and growth and development rules, and puts forward integrated prevention and control measures for main diseases and insect pests. The results show that Bijie white garlic features large bulbs, …
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Bo Wang, Yushu Ding
Abstract.To explore the creep characteristics and mechanism of soft rock from a microscopic perspective, this paper investigates the red mudstone from the Shizishan tunnel section in central Yunnan. A stepwise loading approach was employed to investigate the creep characteristics of the rock samples. A viscous model was established in the 3D particle flow code (PFC), and the discrete element method (DEM) was employed to simulate static fatigue failure of the rock based on experimental data, thereby studying its microscopic creep mechanism. The results show that: (1) Under low stress conditions, the …
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Jianke Zhang, Ruicheng Sun, Tongyu Li, Xiaoqi Lü, Hui Liu
Abstract.Aiming at the problems of traditional lotus root processing, such as reliance on manual labor, low efficiency, and poor accuracy in node cutting, this paper designs an intelligent lotus root node cutting machine control system based on PLC and machine vision. The system integrates three modules: motion control, vision inspection, and human-machine interaction. With Siemens S7-200 SMART PLC as the control core, it handles logic decision-making and motion control. The Jetson Nano embedded platform equipped with the YOLOv5s object detection algorithm is used to identify and locate lotus root …
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Yuwei Wu, Jingyang Xu, Xueyan Jin, Bo Xie, Qiao Yue, Xiaoling Wei, Peitong Liu
Abstract.Against the backdrop of the rapid iteration of intelligent connected vehicles and autonomous driving technologies, Steer-by-Wire (SBW) has become the core technical direction for the upgrading of automotive steering systems. As a global leader in the electric power steering sector, as well as a pioneer and mass-production promoter of SBW technology, JTEKT has laid out a large number of core patents worldwide, forming significant technological barriers and intellectual property advantages. Based on global SBW patent data, this paper combs the technical architecture, analyzes the patent …
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Jingwen Wang, Pingping Yang, Ziyi An, Run Luo, Jiayi Feng, Linghan Zhang
Abstract.Medical Imaging occupies a central position in modern clinical diagnosis and treatment. However, faced with vast and continuously growing volumes of complex imaging data, traditional image processing algorithms reliant on manual features struggle to meet the demands for efficient and precise clinical applications. Against this backdrop, Deep Learning technology, leveraging its unique advantages, has demonstrated immense application potential in Medical Imaging, significantly enhancing the accuracy and efficiency of medical diagnosis. This paper systematically reviews the primary technological …
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Peitao Wu
Abstract.Spreading and cooling is a crucial process in strong-flavor (Nongxiang) Baijiu production, during which volatile aroma substances are emitted and closely related to Baijiu flavor formation and brewing resource utilization. In this study, dynamic sampling was used to collect gaseous substances at six time nodes (0-2 min to 10-12 min) during the spreading and cooling process in a semi-automatic workshop of a southwest Chinese strong-flavor Baijiu distillery. Gas chromatography-mass spectrometry (GC-MS) combined with mass spectrometry (MS) and retention index (RI) was applied for qualitative and …
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Yufei Liu
Abstract.In the current field of petroleum development, water-source identification and water shutoff in horizontal wells have become key difficulties affecting the sustained development of such wells. Intelligent tracer-based water diagnosis and shutoff technology can provide highly intuitive information on the location and intensity of water production along the horizontal section and therefore has broad development prospects. However, the long-term performance of intelligent tracer-based water shutoff in horizontal wells is influenced by many factors, such as erosion by formation fluids and aging of …
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Wei Luo, Yan Hua, Jian Han
Abstract.The toxicity of lead in perovskite solar cells has long been a significant barrier to their widespread commercialization. The improvement of environmentally friendly tandem solar cells presents the additional challenge of identifying highly efficient materials for both the wide-bandgap top cell and the narrow-bandgap bottom cell. In this study, we have reported a lead-free, non-toxic tandem perovskite solar cell , investigated through numerical simulations, by pairing an Sb³⁺-doped double perovskite, Cs2AgBi0.75Sb0.25Br6, with a bandgap of 1.8 eV, as the top cell, with a tin-based MASnI₃ …
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Jabar Yassine, Malik Turner, Gregg L. Semenza
Abstract.We evaluated an eight-component retinal-support formulation that combines lutein, meso-zeaxanthin, β-carotene, blueberry extract, grape seed extract, L-ergothioneine, saffron extract, and phosphatidylserine within a dual-phase microencapsulation platform. We retained the available formulation-characterization dataset for lipid-soluble oxidation, water-soluble retention, 45-minute dissolution, and blue-light–stressed retinal pigment epithelial survival, and we paired those data with published randomized or controlled human trials across the clinically closest ingredient domains. Embodiment 1 …
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Nour-Eddine Ziraoui, Marco DeLuca, Jayden Cruz
Abstract.Background: Ergothioneine, curcumin, and piperine are mechanistically complementary but translationally limited by divergent physicochemical behavior, uneven release kinetics, and bioavailability constraints. We therefore reconstructed a core-shell hierarchical nanolipid system and integrated its formulation performance with available human clinical evidence relevant to the three-active strategy. Methods: We extracted formulation architecture, encapsulation, release, and stability data from the source patent dossier. We then performed a targeted evidence synthesis of published human …
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Haoyuan Yang
Abstract.The natural gas enrichment in the Lingshui Sag of the Qiongdongnan Basin exhibits a prominent spatial pattern characterized as "superior in the south and inferior in the north, dry in the south and mixed in the north." This paper systematically compares the hydrocarbon accumulation conditions on the northern and southern sides to elucidate the mechanisms driving this differential enrichment. Research indicates that the coal-measure source rocks of the Yacheng Formation on the southern side possess tremendous hydrocarbon generation potential. Furthermore, the deep-water gravity flow channel …
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Feifei Han
Abstract.The study of thermal history of sedimentary basins is an important part of basin dynamics and hydrocarbon accumulation analysis, which is of great significance for revealing the maturation and evolution of source rocks, hydrocarbon generation and expulsion processes and hydrocarbon accumulation rules. In this paper, two basic methods of basin thermal history restoration are systematically sorted out: tectonic thermal evolution method and paleotemperature scale method. The tectonic thermal evolution method is based on the dynamic model of the lithosphere scale. By simulating the tectonic …
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Changsong Jin
Abstract.Synthetic ammonia is widely used in the production processes of industrial nitric acid, ammonium salts, fertilizers, etc., playing an indirect role in promoting the development of the national economy. At the same time, as one of the basic raw materials for industrial construction and chemical development, the demand for ammonia in various related industries has also increased by tons. However, as an important participant in industrial development and the national economy, traditional synthetic ammonia often has huge energy consumption and low profitability. Therefore, research and development …
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Jabar Yassine, Gregg L. Semenza, Andre Bishop
Abstract.Background: Sleep-support formulations are often marketed as simple ingredient stacks, yet clinically relevant performance depends on whether precursor support, relaxation support, sleep-maintenance support, and gastrointestinal tolerability are coordinated within a practical oral dose window. Methods: We evaluated the NVTIA ternary system by combining its ratio-defined formulation disclosure and patent-reported preclinical benchmarks with published human clinical evidence on 5-hydroxytryptophan (5-HTP), L-theanine, and gamma-aminobutyric acid (GABA). We retained the original preclinical data …
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Anas Ziraoui, Zara Khan, Rico Valenti
Abstract.Background: Low-grade inflammation, mucosal-barrier disruption, and recurrent gastrointestinal inflammatory symptoms frequently coexist in adults with immune-inflammatory dysregulation. Multi-strain probiotic systems and postbiotic preparations have both shown anti-inflammatory potential in human studies, but formulation-specific evidence remains essential. Objective: We aimed to present a evidence paper for the BALIMONT composition by integrating retained formulation benchmark data with available clinical trials and meta-analyses relevant to its strains, postbiotic strategy, biomarker …
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Lijie Guo
Abstract.Aiming at the inefficiency caused by the separation of schedule and cost control in oil and gas exploration and development projects, a dynamic collaborative management mechanism based on digital twinning and deep reinforcement learning (DRL) is constructed in this study. Through system dynamics modeling, it reveals the dynamic influence of key coupling variables such as geological risk index and engineering complexity on schedule and cost, and puts forward a management framework of "three-layer linkage and dynamic closed loop": using the digital twin platform integrated with Internet of …
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Yuqi Yang, Shilin Yang, Hanmeng Wang, Changhao Wang
Abstract.With the acceleration of urbanization in China, the urban population density has risen sharply, leading to increasingly severe social security and traffic congestion problems. To address these issues, this study proposes a dynamic and accurate regional pedestrian flow prediction model based on the LSTM neural network, which fuses temporal, statistical and semantic features. Meanwhile, the prediction results are applied to assist relevant departments in pedestrian flow management. Experimental results show that the model achieves a mean squared error (MSE) as low as 29.2530 and a mean absolute …
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Jiawei Ren
Abstract.The restoration of the original basin is a core geological task for reconstructing the original appearance of sedimentary basins, revealing the evolution laws of basins, and guiding the exploration of oil, gas and other mineral resources. As a tectonic phenomenon that occurs simultaneously with sedimentation during the evolution of sedimentary basins, syn-sedimentary faults directly control the boundary morphology of the basin, the migration of sedimentary centers, the distribution of strata thickness and the paleogeomorphic features. They are key controlling factors that cannot be ignored in …
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Yuepeng Zhang
Abstract.Based on the author’s doctoral dissertation, this paper examines how system dynamics can be used to optimize regional pooling governance in China’s pension insurance system under unified provincial pooling rules. Using Yingkou City in Liaoning Province as the focal case and drawing on comparative evidence from the province’s 13 prefecture-level cities during 2015-2024, the paper integrates three layers of evidence: efficiency decomposition, influencing-factor identification, and dynamic pathway simulation. The preceding dissertation results show that Yingkou’s main efficiency bottleneck lies …
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Yayang Li
Abstract.Drag reducing agents (DRAs) play a vital role in reducing flow resistance, improving transportation efficiency, and saving energy consumption in product oil pipeline transportation. During long-distance transportation, product oil usually operates in a turbulent state, and turbulent fluctuations and energy dissipation inside the fluid are the main causes of pressure drop along the pipeline. As high-molecular polymers, DRAs can interact with turbulent structures, attenuate turbulent fluctuations, and reduce energy loss, thereby achieving drag reduction and throughput enhancement. Meanwhile, …
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Hanlin Shi
Abstract.Traditional carbon emission accounting has long been constrained by insufficient spatiotemporal resolution, limited coverage, and inadequate dynamic monitoring capabilities. Remote sensing technology, leveraging its inherent advantages of non-contact observation, synchronous wide-area sensing, and multi-scale dynamic tracking, has been deeply integrated into the entire process of carbon emission accounting, emerging as a pivotal force for addressing these challenges. Combined with practical application examples of technologies such as night light remote sensing and LiDAR, it deeply analyzes …
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Xinxiong Lv
Abstract.The intensification of global climate change and environmental pollution has made achieving carbon peaking and carbon neutrality a core strategy for global development. With the continuous advancement of new energy technologies, the utilization of clean energy sources such as wind, solar, and hydrogen has brought profound transformations to the traditional energy structure. In this context, the fields of aero engines and gas turbines are also facing both pressure and opportunities for low-carbon transition. This paper analyzes new energy power generation technologies under the “dual carbon” …
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Zhenyu Huang, Jian Yin
Abstract.To achieve coordinated optimization of workability and mechanical performance in fair-faced concrete, an ordinary Portland cement-based binder system incorporating fly ash (FA), ground granulated blast-furnace slag (BFS), metakaolin (MK), and diatomite (DE) was developed to prepare low-carbon fair-faced concrete with multiple mineral admixtures. An L16(44) orthogonal design was employed to systematically investigate the effects of these factors on spread diameter, T500, compressive strength at 3, 7, and 28 days, and splitting tensile strength at the same ages. Range analysis, analysis of …
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Yuxin Zhang, Xiaonan Lei, Bokai Zheng, Dongdong Yan
Abstract.Against the backdrop of the rapid development of the new energy vehicle industry, the recycling of waste power batteries has gradually become a research hotspot. The service level of recycling enterprises and the energy density of power batteries are key factors influencing the recycling efficiency and overall profit of the closed-loop supply chain. Taking the closed-loop supply chain of power batteries as the research subject, this paper considers the energy density of power batteries and the recycling service level, and constructs three game models of closed-loop supply chains where power …
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Jingwei Ren, Fengru Ding, Lili Wei
Abstract.Wind power intermittency and uncertainty significantly increase the complexity of power grid dispatch and impose more stringent requirements on the secure and stable operation of power systems. To address this challenge, this paper proposes a scenario-oriented dynamic selection and fusion decision framework based on dynamic quantile thresholds and a performance matrix. First, a forecasting model pool consisting of physical mechanism models, statistical regression models, and individual deep learning models is constructed, and the applicable boundaries of different model categories are …
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Guangming Zhao
Abstract.Street canyons, as a key component of the urban built environment, strongly influence the diffusion and retention of particulate pollutants due to their complex airflow structures. To investigate the diffusion mechanisms of particulate matter released from different locations within street canyons, a two-dimensional idealized canyon model without vegetation was employed. A steady-state flow field was simulated using computational fluid dynamics (CFD), and a Lagrangian particle-tracking approach was applied to analyze particle trajectories and transport behaviors at different spatial positions. …
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Anas Ziraoui, Maksim Orlov, Brandon Pierce
Abstract.We evaluated the translational basis of a BALIMONT immune-support composition that combines Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus rhamnosus, heat-inactivated Lactococcus lactis, prebiotic substrates, and a double-layer encapsulation system. Rather than presenting an unverified trial as completed research, we integrated the formulation's retained technical findings with publicly available randomized controlled trials, pilot studies, and meta-analytic evidence relevant to mucosal IgA, secretory IgA, bifidobacterial enrichment, and immune challenge responses. The retained …
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Ziyi Wang, Junjie Xu, Zongyao Ji, Xuesong Wu
Abstract.Against the background of the rapid popularization of intelligent connected vehicles, the in-vehicle electronic and electrical architecture is continuously upgraded to domain control and centralization, putting forward higher requirements for information security in links such as in-vehicle data interaction, vehicle-cloud communication, firmware upgrade, and identity authentication. As the hardware root of trust in the in-vehicle information security system, encryption chips undertake key functions such as key storage, encryption and decryption operations, digital signature, secure boot, and …
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Xiaohua Du
Abstract.Abnormal high-pressure systems are widely developed within the Cenozoic strata of the northwestern Qaidam Basin (NW Qaidam), which is a key geological factor constraining hydrocarbon exploration and drilling safety. This study systematically investigates their distribution characteristics, genetic mechanisms, and controlling effects on hydrocarbon accumulation by comprehensively utilizing a large amount of geological, geophysical, and basin modeling data. The results indicate that the abnormal pressure in the NW Qaidam exhibits a four-segment vertical zonation: low pressure in shallow …
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